A process for the preparation of physiologically active compounds, called ML-236 A, B ML-236 and ML-236 C.

摘要

Physiologically active substances ML-236 of the formula WHEREIN R is hydrogen atom, hydroxy group or 2-methylbutyryloxy group having cholesterol- and lipid-lowering effects in blood and liver and thus utility as hypocholesteremic and hypolipemic medicaments. They are obtained by cultivation of an ML-236-producing microorganism belonging to the genus Penicillium in a culture medium and subsequent recovery thereof from a cultured broth.