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still for framstellning of peptides with psychopathological characteristics
still for framstellning of peptides with psychopathological characteristics
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机译:仍用于对具有精神病理学特征的肽进行细读
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摘要
The invention relates to novel peptides and peptide derivatives of the general formula: A-L-Glu(Q)-L-His-D-X,I in which L and D indicate the configuration of the relative residue, A stands for: H-L-Met, H-L-Met(-O), H-L-Met(-O2), Dam, Dam(-O), Dam(-O2) or the moiety H-L-NH-B-CO-, in which B is a branched or unbranched alkylene group with 1-6 carbon atoms, Q respresents the group OH or NH2, and X is selected from a (N-phenyl branched alkyl) amino group with the general formula (IN WHICH R represents a branched alkylene group with 2-6 carbon atoms and R1 hydrogen, hydroxy, halogen or an alkyl or alkoxy (1-4 C) group), and the group -Phe-Y, in which Y represents a hydroxy group, a (N-aminoalkyl)amino moiety (in which the alkyl group may contain 2-6 carbon atoms) or the group L-Lys-Z or L-Arg-Z, in which Z stands for a hydroxyl group, the group L-Phe-OH, a (N- beta -indolylalkyl)amino moiety or a (N-phenylalky) amino moiety, the alkyl group of both moieties containing 1-6 carbon atoms, AS WELL AS THE FUNCTIONAL DERIVATIVES THEREOF.
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