首页>
外国专利>
PROCEDURE FOR THE PROMOTION OF FENYLPIPERAZING DUTIES
PROCEDURE FOR THE PROMOTION OF FENYLPIPERAZING DUTIES
展开▼
机译:促进粉刺行刑的程序
展开▼
页面导航
摘要
著录项
相似文献
摘要
Phenylpiperazine derivatives of formula (I) IMAGE as well as their pharmaceutically acceptable salts, are prepared. R1 represents benzyl, C1-6 alkyl or an optionally substituted phenyl; R2 represents an optionally substituted phenyl, R3 represents hydrogen or C1-4 alkyl, Q represents furan, thiophene, oxazole or thiazole, m is an integer from 1 to 3 and n is 0 or 1. When m is 2 and n is 0, R1 cannot represent a methyl group when Q is the thiazol-5-yl group. The preparation is carried out by condensation of a compound of formula (VII): R1-Q-(CH2)m-(CHR3)n-L (VII) in which L represents the split group, with a compound of formula (VIII): IMAGE The compounds of formula (I) and their pharmaceutically acceptable salts are useful in the prophylactic and therapeutic treatment of diseases of immediate hypersensitiveness, especially asthma in mammals. They have a low toxicity.
展开▼
机译:制备式(I)的苯基哌嗪衍生物及其药学上可接受的盐。 R 1代表苄基,C 1-6烷基或任选取代的苯基; R 2表示任选取代的苯基,R 3表示氢或C 1-4烷基,Q表示呋喃,噻吩,恶唑或噻唑,m是1-3的整数,n是0或1。在图2中,n为0时,当Q为噻唑-5-基时,R 1不能代表甲基。通过使式(VII)的化合物:R 1 -Q-(CH 2)m-(CHR 3)n L(VII)(其中L表示拆分基团)与以下化合物缩合来进行:式(VIII):<图像>式(I)化合物及其药学上可接受的盐可用于预防和治疗即时过敏性疾病,尤其是哺乳动物的哮喘。它们具有低毒性。
展开▼