Procedure for the preparation of new pseudotrisacaridos. (Machine-translation by Google Translate, not legally binding)

摘要

Procedure for the preparation of new pseudotrisaccharides, particularly 1-N substituted derivatives of 4,6-di- (aminoglycosyl) -1,3-diaminocyclitols gentamicin A, gentamicin B, gentamicin B1, gentamicin C1, gentamicin C1a, gentamicin C2, Gentamicin C2a, Gentamicin C2b, Gentamicin X2, Sisomycin, Verdamicin, Tobramycin, G-418 Antibiotic, 66-40B Antibiotic, JI-20A Antibiotic, JI-20B Antibiotic, G-52 Antibiotic, Mutamycin 1,, mutamicin 4, mutamicin 5, and mutamicin 6, in which the substituent is straight-chain alcohol having up to five carbon atoms, and of the pharmaceutically acceptable acid addition salts thereof, which method comprises reacting one of the 4,6-di- (aminoglycosyl) -1,3-diaminocyclitols listed above, which has amino protecting groups at any position other than position 1, and in which the 1-amino group may be activated, with an alcoholizing agent what conti It has the straight-chain alcohol group having up to five carbon atoms and one active group, remove the protecting groups and, if required, the activating group or groups present in the molecule, and isolate the derivative as is or in the form of a pharmaceutically acceptable acid addition salt. (Machine-translation by Google Translate, not legally binding)