pentaacetylisopurpuromycin, a method for the production of pharmaceutical compositions containing pentaacetylisopurpuromycin and this connection

摘要

Antibiotic substances referred to as purpuromycin and its derivatives, which derivatives are obtained by heating purpuromycin under mild basic conditions and by acylation. The purpuromycin derivative obtained by heating the compound under mild basic conditions is hereinafter referred to as isopurpuromycin, while the two acetyl derivatives obtained by acetylation of purpuromycin and of isopurpuromycin are referred to, respectively, as acetyl derivative II and acetyl derivative I. Other acyl derivatives may be obtained wherein the acyl group is derived from C2-C4 mono- or di-carboxylic aliphatic acids which may contain a double bond in the chain or may carry a hydroxy substituent radical. The antibiotic substance purpuromycin is prepared by cultivating Actinoplanes ianthinogenes nov. sp. A/1668 under submerged aerobic conditions in aqueous nutrient medium containing an assimilable source of carbon, nitrogen and inorganic salts and recovering purpuromycin therefrom.