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Means for foerderung of the growth or to improve the effectiveness of the feed conversion in animals
Means for foerderung of the growth or to improve the effectiveness of the feed conversion in animals
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机译:促进动物生长或提高饲料转化效率的手段
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1495305 5,7-Dihydroxy-3-phenyl-4-oxo-4H- benzopyran carboxaldehydes PFIZER Ltd 10 Sept 1976 [12 Sept 1975] 37552/75 Heading C2C [Also in Division A5] Novel compounds of the Formula II wherein R is formyl in the 6- or 8-position and RSP1/SP is an optional halogen in the 8- or 6-position respectively ; RSP3/SP is hydrogen or alkyl; RSP4/SP is halogen, hydroxy, C 2-8 -alkanoyloxy, alkyl, alkoxy, nitro, amino, C 2-8 alkanoylamino, sulphonylamino or (SO 2 NRSP5/SPRSP6/SP wherein RSP5/SP and RSP6/SP are hydrogen or alkyl or RSP5/SP and RSP6/SP together with the nitrogen atom form a saturated heterocyclic group and n is 0 to 3, or any two of the moieties RSP4/SP represent alkylenedioxy attached to adjacent carbon atoms of the benzene ring, wherein alkyl alkoxy and alkylene groups have 1 to 4 carbon atoms, may be prepared by (1) where R 1 is hydrogen and (RSP4/SP) n does not contain a free amino or a sulphamoyl group, by heating a compound V with hexamine in glacial acetic acid or by reacting V with hydrogen cyanide, a cyanogen halide or zinc cyanide in the presence of hydrogen chloride or a Lewis acid; (2) where R 1 and R 2 are hydrogen and (RSP4/SP) n is other than or does not contain hydroxy, acyloxy, amino or sulphamoyl, reacting a compound III wherein (RSP9/SP) n is as defined for (RSP4/SP) n immediately above, with at least two molar proportions of dimethyl formamide in the presence of a p-toluene sulphonyl chloride; (3) where R 1 is halogen, by halogenation of compounds II in which R 1 is hydrogen; (iv) where (RSP4/SP) n is or includes amino, by the reduction of the corresponding nitro substituted compound II; (v) optional acylation of the product of (iv) to form an alkanoylamino or sulphonylamino group; (vi) where (RSP4/SP) n is or includes sulphamoyl, by chlorosulphonation followed by reaction with ammonia or a dialkyl or cyclic amine. 5 - Hydroxy - 3 - (4 - methoxyphenyl) - 7 - noctanoyloxy - 4 - oxo - 4H - benzopyran - 8 - carboxaldehydedihydrate, pharmaceutical compositions of which are claimed, is prepared by esterification of the corresponding 5,7-dihydroxy compound.
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