Beta-blocking chloropractolol and salts - for treatment of cardiac arrhythmias, angina, hypertension and post infarction patients

摘要

1-N-Isopropylamino-3-(4-chloroacetamidophenoxy)propan-2-ol (chloropractolol) and its salt are new. They are used as beta 1-blockers for treatment of cardiac arrhythmias, angina pectoris, hypertension and post-infarction patients. In an example Chloropractolol is prepared by a 4-stage process via 4-nitrophenoxymethylloxirane, 1-isopropylamino-3-(4-nitrophenoxy)-propan-2-ol and 1-2sopropylamino-3-(4-aminophenoxy)propan-2-ol from 4-nitrophenol and epichlorhydrin.