N,N-disubstituted derivatives of 3-carboxamide or 3- thiocarboxamide-7-(3- chloro-2-propenyl)-1,3,5,7-tetraazabicyclo(3.3.1) non ane and preparation II

摘要

Compounds of the formula ##STR1## where X represents O or S and R.sub. 1 and R.sub.2 each represents lower alkyl, phenyl or (lower alkyl)phenyl. The compounds are prepared by reacting the ring-opened intermediate (obtained by reacting cis-1-(3-chloro-2-propenyl)-3,5,7- triaza-1- azoniatricyclo(3.3.1.1.sup.3,7)d ecane chloride with excess aqueous sodium hydroxide) with an equivalent amount of a corresponding carbamoyl halide or thiocarbamoyl halide or at a low temperature to give the indicated tetrasubstituted urea or thiourea product. The compounds have antimicrobial utility.