1-H Pyrazolo[3,4-e][1,4]thiazepin-7(8H)-ones which may be substituted in the 1, 3, 4, 6 and 8-position, and the corresponding isoxazolo[5,4-e][1,4]thiazepin-7(8H)-ones which may be substituted in the 3, 4, 6 and/or 8-position are prepared by converting 5-aminopyrazole which may be substituted in the 1- and/or 3-positions or a 5-aminoisoxazole which may be substituted in the 3-position into 4-arylidene or alkylidine-5-imino derivatives and subsequent condensation with thioglycolic acid or a substituted thioglycolic acid. The new compounds are useful anti-inflammatories.
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