PHARMACEUTICAL PREPARATIONS CONTAINING A BETA-RECEPTOR BLOCKING COMPOUND AND A COMPOUND REGULATING THE THROMBOCYTE FUNCTION AND, OPTIONALLY, AN ALPHA-RECEPTOR BLOCKING COMPOUND, FOR THE TREATMENT OF CORONARY HEART DISEASES

摘要

1510370 Compositions for treating coronary heart disease CIBA - GEIGY AG 31 Dec 1975 [6 Jan 1975] 53300/75 Heading A5B Pharmaceutical preparations for the treatment of coronary heart disease contain (1) a beta - receptor blocking compound of the formula:- wherein Ar 1 represents a monocyclic or polycyclic, carbocyclic or heterocyclic radical which contains at least one ring of aromatic character, and which is 'bonded to the oxygen atom via a ring carbon atom, preferably of the ring of aromatic character R 1 denotes an optionally substituted aliphatic, cycloaliphatic or araliphatic hydrocarbon radical and R 2 represents hydrogen or the acyl radical of an organic carboxylic acid, or a compound of the formula wherein R 1 and R 2 have the abovementioned meanings, Ar 2 represents a monocyclic or polycyclic, carbocyclic radical which contains at least one ring of aromatic character, and R 3 denotes hydrogen or lower alkyl, or a salt of such compounds which can be used pharmaceutically, (2) a compound which regulates the thrombocyte function which is acetylsalicylic acid or a salt thereof with a base which can be used pharmaceutically, 2, 6 - bis- [di - (2 - hydroxyethyl) - amino] - 4, 8 - di - piperidino - pyrimido [5, 4 - d] pyrimidine, or an acid addition salt thereof which can be used pharmacetically or a compound of the formula wherein each of the radicals Ph 1 and Ph 2 independently of one another represents a phenyl radical which is optionally substituted by lower alkyl, hydroxyl, lower alkoxy and/or halogen, Alk denotes a lower alkylene radical which separates the sulphur atom from the ring carbon atom by at least 2 carbon atoms, n represents 0, 1 or 2 and Ph 3 represents a phenyl radical which is optionally substituted by lower alkyl, lower alkoxy and/or halogen, or a salt thereof with a base, which can be used pharmacologically, and optionally (3), an alpha - receptor blocking compound which is a hydrogenated ergot alkaloid, or a mixture of such alkaloids or acid addition salts thereof which can be used pharmaceutically, or a N - benzyl - N - halogeno - lower alkylamine, a 2 - tert. - aminomethyl - benzodioxane, a N - substituted dibenzazepine or a methyl - 2 - imidazoline which is substituted in the 2 - position or acid addition salts of such compounds which can be used pharmaceutically.