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method of preparation of new oximes of 7 amino acid derivees (acetamido cephalosporanique
method of preparation of new oximes of 7 amino acid derivees (acetamido cephalosporanique
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机译:七种氨基酸衍生新肟的制备方法(对乙酰氨基头孢
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摘要
The compounds correspond to the formula: IMAGE in which the symbols R, R1 and A have the meaning given in Claim 1. They are prepared by reacting compounds of formula II and III: IMAGE or a functional derivative of III, in which A' represents H or an ester which can be removed by acid hydrolysis or by hydrogenolysis, R2 represents a group which can be removed in the same way or a chloroacetyl group and R'1 is defined like R2 or represents a saturated or unsaturated C1-C4 alkyl and when R'1 represents ClCH2CO-, R2 also represents this group; the removable groups A', R2 and R'1 are then removed by acid hydrolysis, hydrogenolysis and/or treatment with thiourea. The compounds and their salts of the carboxylic group have a good antibiotic activity and can be used for the treatment of various infectious diseases.
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