the new oximes derivees acid, 3 - (azidomethyl 7 - amino acetamido cephalosporanique, their method of preparation.their application as medicines and pharmaceutical compositions containing them

摘要

3-Azidomethyl-7- 2-(2-amino-4-thiazolyl)-2-oximino-acetamido -3-c- ephem-4-carboxylic acid derivs. (syn isomers) of formula (I) and their acid-addn. salts are claimed: (where R is H, opt. unsatd. 1-4C alkyl, (CH2)nR1 or benzoly; R1 is COOA' or NH2; n = 1-4; A and A' are H, an equiv. of an alkali(ne earth) metal, Mg, NH4 or organic ammonium cation, or a readily cleavable ester residue). Also claimed are new intermediates for the prepn. of (I). (I) are active against Gram-positive and -negative Lacteria, e.g. with MIC values of =0.5 mu g/ml against Staph. aureus, E. coli, K. pneumoniae, Proteus mirabilis and Salm. typhimurium, including antibiotic-resistant strains of these spp. They can be used as antibacterial medicaments and disinfectants.