tioli as intermediate in preparation of selective agents on histamine receptors and process for the production of these tioli

摘要

New furan derivs. of formula (I), and their N-oxides, hydrates and salts: (where R1 andR2 are H, lower alkyl, cycloalkyl, lower alkenyl, aralkyl, or a lower alkyl gp. interrupted by O or NR4, or NR1R2 is a heterocyclic ring opt. contg. an O atom or NR4 gp; A is 1-6C alkylene; R3 is H, lower alkyl, lower alkenyl or alkoxyalkyl; R4 is H or lower alkyl; X is CH2, O or S; Y is S, O, NR5 or CHR6; R5 is H, NO21 CN, lower alkyl, aryl, alkylsulphonyl or arylsulphonyl; R6 is NO2, arylsulphonyl or alkylsulphonyl; m = 2-4, n = 1 or 2 or can be O when X is S or CH2). (I) are histamine H2 receptor antagonists. They inhibit histamine-induced gastric hypersecretion without affecting smoth-muscle contraction induced by histamine. They can also be used to treat allergic symptoms, e.g. urticaria.