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21-Unsatd. fatty acid ester(s) of dexamethasone and betamethasone
21-Unsatd. fatty acid ester(s) of dexamethasone and betamethasone
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机译:21周六。地塞米松和倍他米松的脂肪酸酯
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摘要
Unsatd. fatty acid esters of dexamethasone and betamethasone of formula (I) are new. (where R=opt. uns unsatd. 8-14C alkyl; n=3-7 and the 16-CH3 group has alpha or beta configuration)Cpds. (I) are antiinflammatories, antiperspirants and antiprurities which are applied topically; optionally with other active cpds. (I) give good penetration and prolonged activity the ester being slowly hydrolysed to release the active cpd.
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机译:不好意思式(I)的地塞米松和倍他米松的脂肪酸酯是新的。 (其中R =不饱和的8-14C烷基; n = 3-7并且16-CH 3基团具有α或β构型)Cpds。 (I)是局部使用的抗炎药,止汗药和止血药;可选与其他活动cpds一起使用。 (I)使酯缓慢水解释放出活性的cpd,从而具有良好的渗透性和延长的活性。
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