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An antiarrhythmic quinuclidine carbonsaeure - xylidide as well as a method for the preparation of these and similar compounds
An antiarrhythmic quinuclidine carbonsaeure - xylidide as well as a method for the preparation of these and similar compounds
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机译:一种抗心律失常的奎宁环苷碳二甲苯醚以及这些化合物和类似化合物的制备方法
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摘要
ANTIARRHYTHMIC QUINUCLIDINE CARBOXYLIC ACID XYLIDIDE AND METHOD OF PRODUCING THE SAME AND SIMILAR COMPOUNDS The invention relates to the compound 2-6-xylidide of quinuclidine-3-carboxylic acid and its pharmaceutically acceptable salts, such as the hydrochloride, which have been found to be effective antiarrhythmic agents. The invention further relates to the production of this antiarrhythmic compound which method is applicable also to the production of related compounds which, however, do not have antiarrhythmic action, e.g. the quinuclidine-2-carboxylic acid xylidides. The compounds are produced according to this method by reacting the quinuclidine carboxylic acid in anhydrous chloroform and oxalyl chloride with the dimethylaniline. The desired compound is produced in high yield with a high degree of purity.
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