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Antiarrhythmic quinuclidine carboxylic acid xylidide and method of producing the same and similar compounds
Antiarrhythmic quinuclidine carboxylic acid xylidide and method of producing the same and similar compounds
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机译:抗心律失常的奎宁环羧酸二羟甲基化物及其制备方法
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摘要
The invention relates to the compound 2-6-xylidide of quinuclidine-3- carboxylic acid and its pharmaceutically acceptable salts, such as the hydrochloride, which have been found to be effective antiarrhythmic agents. The invention further relates to the production of this antiarrhythmic compound which method is applicable also to the production of related compounds which, however, do not have antiarrhythmic action, e. g. the quinuclidine-2-carboxylic acid xylidides. The compounds are produced according to this method by reacting the quinuclidine carboxylic acid in anhydrous chloroform and oxalyl chloride with the dimethylaniline. The desired compound is produced in high yield with a high degree of purity.
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