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Catalytic hydrogenation of 6-methylenetetracyclines - using rhodium-tert phosphine complex catalyst giving a stereospecific prod. in high yield
Catalytic hydrogenation of 6-methylenetetracyclines - using rhodium-tert phosphine complex catalyst giving a stereospecific prod. in high yield
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机译:6-亚甲基四环素的催化加氢-使用铑-叔膦配合物催化剂产生立体有规的产物。高产
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摘要
6-Methylenetetracyclines are hydrogenated by treating a tetracycline with an exocyclic methylene group with H2 in the presence of a catalyst consisting of a complex of rhodium with a tertiary phosphine of formula PR1R2R3, (where R1 and R2 are phenyl opt. substd. by e.g. alkyl, alkoxy, halogen or dialkylamino gps; and R3 and R gamma are alkyl or benzyl gp), in a solvent which dissolves both the tetracycline and the catalyst. The process produces little or no undesired anhydrotetracyclines, the reduction is practically quantitative and the catalyst is stereoselective to the production of the 6 alpha-epimer.
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机译:通过在由铑与式PR 1 R 2 R 3的叔膦的配合物组成的催化剂存在下(其中R 1和R 2是苯基最优选被例如烷基取代的苯基)构成的催化剂存在下,通过用H 2用环外亚甲基基团处理四环素而氢化6-亚甲基四环素。 ,在溶解四环素和催化剂的溶剂中,烷氧基,卤素或二烷基氨基gps;和R3和Rγ是烷基或苄基gp)。该方法几乎不产生或不产生不想要的脱水四环素,该还原反应实际上是定量的,并且该催化剂对6-α-表观异构体的产生具有立体选择性。
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