Pharmaceutical compsn. contg. self-emulsifying oil e.g. silicone - for admin. as capsules, giving rapid gastrointestinal resorption

摘要

Pharmaceutical compsn. contains a unit dose of the active ingredient (I) and a self-emulsifying oil (II). Suitable (II) are steroids; antimycotics; tranquilisers, sedatives; diuretics; anti-inflammatories; analgesics; antibiotics and insulin; specifically dexamethasone, prednisolone, griseofulvin, diazepam, chlordiazepoxide, furosemide, indomethacin, lipophilic penicillins and bleomycin. (I) and (II) are presented in soln. or suspension, and (II) consists of an oil (IIa), e.g. a silicone or triglyceride, and a surfactant (IIb), pref. nonionic e.g. polyethoxylated alkylphenols. For rectal, vaginal and esp. oral administration; the compsns. can be filled into capsules to give highly reproducible doses, and when ingested have improved resorption from the gastro-intestinal tract.