Method of producing intravenously injectable gamma globulin and a gamma globulin suitable for carrying out the method

摘要

A process is provided for the preparation of a gamma globulin suitable for intravenous administration from the readily available Fraction II or II + III plasma protein paste. The Fraction II or II + III paste is extracted with water at a pH of 4.8 - 6.5 and impurities are fractionally precipitated by addition of polyethylene glycol to 4% of wt. /vol. and then 5% wt./vol. The desired gamma globulin is then precipitated at a pH 8.0 by addition of polyethylene glycol to 12% wt. /vol.