METHOD OF MANUFACTURING NOVEL ANTIITUMOR ANTIBIOTICS* VII7501

摘要

1513344 Biochemical composition HITACHI CHEMICAL CO Ltd 31 Aug 1976 [3 Sept 1975] 35929/76 Heading C3H A biochemically active composition V1-7051 is made by growing a culture of Streptomyces griseus, bachijoeusis, collinus, griseoruben, lin. coleneusis, cinereornber, imichiganesis, lavendulae, xanthochromogenus, viridifaciens, netropsis, flavogenseus, vendargensis or Actinanices albolayus or coerukscens, in a nutrient medium at 28‹ to 29‹ C. for 24 to 60 hours and then recovering the fraction having a molecular weight range of 1À5 x 104 to 3À5 x 104 from the cultivation liquid, cell walls and cell bodies. The product may be soluble in water and insoluble in methanol, ethanol, acetone, ethyl acetate, benzene and chloroform and it may show a positive reaction with anhydrin o# fluorescamine and negative reaction with anthinone V1-7051 inhibits the activity of succinic dehydrogenase in a tumour cell and its physical and chemical characteristics are detailed. Unlike other antitumour polypeptides it has no antimicrobial activity. Examples are given.