A liver-cell proliferation stimulating factor and medicines containing this factor as active ingredient

摘要

For isolation of a factor to stimulate the proliferation of liver cells, the remaining livers of partially hepatectomized animals or the blood plasma of partially hepatectomized animals or the livers of fetal animals or the blood plasma fetal animals are homogenized. After the action of neuraminidase or Neuraminyltransferase, acidification to pH = 5.5, and heat denaturation at 95 ° C a protein or proteid having a molecular weight of about 30,000 to 50,000 D, which causes a considerable increase of the mitotic rate of liver cells produced.