11-Deoxy-prostaglandin analogues - useful for treating e.g. asthma, more stable and selective and longer lasting than natural cpds.

摘要

Prostaglandins of formula (I) and their pharmaceutically acceptable salts with bases when R1 = H, are new. In the formula R1 = H or alkyl. R2 + R3 are together oxo or -SCH2CH2S or one is H and the other is OH. R4 = H or alkyl. R5 and R6 are each H or alkyl. R7 = H or alkyl. n = 3-6. m = 0-8, and A = CN, COOH, alkoxycarbonyl, N-disubstd. carbamoyl, OH or acyloxy. (I) are made e.g. by reacting a substd. 3-formylcyclopentanone with a Wittig reagent contg. -CO.CR5R6(CH2)mCHR7A (A protected where necessary) then reducing the oxo gps. Used esp. for treating asthma; excessive gastric secretion; as antihypertensives; to induce labour; as contraceptives; to synchronise oestrus (in veterinary medicine) and to treat arteriosclerosis. Compared with natural PG's they are more stable, more selective (fewer side effects) and have a longer lastic action.