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2-Alkyl-5-phenyl-6-para-di:alkyl-aminophenyl triazinone and 3-thione - which are analgesics and blood platelet aggregation inhibitors used in rheumatism and atheroma prevention
2-Alkyl-5-phenyl-6-para-di:alkyl-aminophenyl triazinone and 3-thione - which are analgesics and blood platelet aggregation inhibitors used in rheumatism and atheroma prevention
2-Alkyl-5-phenyl-6-(4-dialkylamino-phenyl)-1,2,4-triazin -3-one and 3-thione derivs. fo formula (I) and their acid addn. salts are new (where R is lower alkyl; R1 is opt. branched lowr alkyl, alkenyl alkynyl or -(Ch2)n-NR2R3; R n is 2-4; R2, R3 are lower alkyl or together with the N atom form a heterocyclic ring; Y is H, halo, lower alkyl, alkoxy or -N(R)2 and X is O or S. Used as analgesics and blood platelet aggregation inhibitor used to treat rheumatic troubles, various pains and in the prevention of atheroma. (I) is administered orally, parenterally or rectally in classical formulations e.g. unit doses of 50-200 mg are administered orally to give a max. daily dose of 1000mg.
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机译:2-烷基-5-苯基-6-(4-二烷基氨基-苯基)-1,2,4-三嗪-3-一和3-硫酮衍生物。式(I)及其酸加成物。盐是新的盐(其中R是低级烷基; R1是支链的低级烷基,烯基炔基或-(Ch2)n-NR2R3; R n是2-4; R2,R3是低级烷基或与N原子一起形成用作镇痛药和血小板凝集抑制剂,用于治疗风湿病,各种疼痛和预防动脉粥样硬化;杂环基;杂环; Y为H,卤素,低级烷基,烷氧基或-N(R)2,X为O或S。 (I)以经典制剂口服,肠胃外或直肠施用,例如口服50-200mg的单位剂量以产生最大每日剂量1000mg。
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