SERUM ALBUMIN POLYMERS SERUM ALBUMIN COMPOSITIONS AND METHODS FOR THEIR PREPARATION

摘要

New serological albumin compositions are provided which have greater potentiating capabilities than existing compositions in agglutination reactions of the IgG class of immune globulins. The essential component is at least one covalently bonded serum albumin polymer. The novel polymers are those containing from two to about eight or more monomeric albumin units which are joined to each other through a covalent peptide bond. Serological compositions may be prepared by polymerization of a dilute aqueous albumin solution, quenching of the reaction, precipitation of the products as solids, dissolution of albumin solids with or without separation of polymers in physiological or isotonic solutions. The compositions are useful as diluents for reagent preparation and for titration media, and as antibody detecting media.