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Process for the preparation of tablets with delayed release of the active agent in the tablets the release rate of the active agent are determined in advance
Process for the preparation of tablets with delayed release of the active agent in the tablets the release rate of the active agent are determined in advance
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机译:延迟释放活性剂的片剂的制备方法预先确定活性剂的释放速率
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摘要
A process for the preparation of matrix-type tablets with retarded liberation of the active agent. The liberation of the active agent from the tablets takes place at a speed that has been adjusted precisely in advance. In the granulation process, polymethacrylate plastics insoluble in neutral or slightly acid water either as dissolved in an organic solvent or as a water dispersion are used as the retarding matrix substance. Before the tablets are compressed, an ester of a large-molecule fatty acid or a product obtained from same by means of hydrogenation is mixed into the grain mix in order to adjust the rate of liberation of the active agent.
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