3-(N'-(3-HALO(OR HYDROXY)PROPYL)-N'-METHYLAMINO)-N,N,N-TRIMETHYL-1-PROPANAMINIUM HALIDE AND NOVEL POLYMERS THEREOF BEING POLY-(METHYL-(3-TRIMETHYLAMMONIOPROPYL)-IMINO)TRIMETHYLENE COMPOUNDS,THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING CERTAIN SUCH POLYMERS

摘要

Novel linear, unbranched, non-cross-linked polymers particularly poly-[{methyl-(3-trimethylammoniopropyl)imino} trimethylene dihalide] are prepared by the polymerization of the novel monomer, 3-[N'-(3-halopropyl)-N'-methylamino]-N,N,N-trimethyl-l-propanaminium halide, or an acid addition salt thereof preferably in an oxygen excluded environment, e.g., under nitrogen or argon. The polymer, especially after modification of terminal groups, is an excellent oral anticholesterolemic.