Membrane stabilizing compounds having beta-receptor blocking activity, their preparation, method for treatment of arrhythmic conditions, and pharmaceutical preparations containing same

摘要

TThe present invention relates to new potent membrane stabilizing compounds of the formulawherein R¹ is alkoxyalkyl. hydroxyalkyl or alkyl, which alkyl groups may be branched or straight, R² is halogen or hyd- rogsn, R³ is hydrogen or alkyl, R⁴ and R⁵ are sams or different and are each hydrogen, sikoxy, alkyl, alkoxyalkyl, cyano, or hydroxy, n is 0, 1, 2, or 3. and X is -O-, -CH_r. or .;The present pounds are potent heart antia^rrhythmic agents possessing membrane stabilizing effect and β-recsptor blocking effect in same clinical doses. The compounds are used In treating antiarrhythmic conditions. but can also be used in the trestment of hypertension. angina pectoris, or nervous heart The invention also relates to processes for preparing the compounds, method of treating anti- arrhythmic conditions and pharmaceutical preparations con- taining said compounds.