Inhibiting gastrointestinal degradation of medicaments - by co:administration of additives undergoing sacrificial degradation

摘要

Method of increasing the biological availability of interally administered medicaments which are degradable (esp. reducible) by the contents of the stomach or intestines, comprises administering the medicaments together with additives which undergo degradation (esp. redn.) in preference to the medicaments. Relevant medicaments include chloramphenicol, aureomycin, tetracycline antibiotics, digoxin, barbiturates, stilbenes, vitamins, nitrofurantoin, 1,4-benzodiazepines, nitroglycerin and nitrate and nitrite esters. Suitable additives include cystine, dehydroascorbic acid, riboflavine and pyridoxal.