A method for modifying the antigen properties of a quercitin radical containing a grass pollen - antigen, or fragment thereof, the resulting modified grass pollen - antigen, its use for the treatment of the grass pollen of all energies and the modified grass pollen - antigen immuno therapeutic agent containing

摘要

Oxidative rearrangement and cleavage of hydroxy aromatic rings of quercitin moiety of Timothy grass pollen antigen or antigen fragments gives rise to a modified antigen having no antigenic properties but retaining capability of activating T-cells for regulation of immune response. The invention includes the modified antigens, the method of oxidative cleavage, immunotherapeutic methods for alleviating allergic responses to the Timothy grass pollen antigens and immunotherapeutic compositions therefor.