The antibiotic substance sf - 1771 and the antibiotic substance sf - 1771 - b, as well as the preparation of these substances

摘要

A new antibiotic SF-1771 substance is produced by cultivating a new strain, Streptomvces tovocaensis SF-1771 in a liquid culture medium under aerobic conditions, and this antibiotic may be isolated from the fermentation broth by treating the broth filtrate with a synthetic adsorbent resin for adsorption of the active compound and eluting the resin with an aqueous alcohol or aqueous acetone, followed by chromatographic purification. SF-1771 substance is a copper-containing ` antibiotic which shows antibacterial activity to Escherichia coli, Salmonella typhi, Pseudomonas aeruginosa, Staphylococcus aureus and Bacillus subtilis. Removal of the copper component from SF-1771 substance by treatment with hydrogen sulfide, an alkali metal sulfide or a copper-chelating agent gives SF-1771-B substance containing no copper component which shows antibacterial activity as high as but a lower toxicity than SF-1771 substance.