Method of increasing renal blood flow with dopamine derivatives

摘要

Certain N,N-dialkyl substituted derivatives of dopamine (DA) increase renal blood flow without affecting cardiac contractility. Particularly effective are N,N-di-n-propyl DA; N-n-propyl-N-n-butyl DA; N- n-propyl-N-n- pentyl DA; N-n-propyl-N-isobutyl DA; and N-n-propyl-N- phenethyl DA. Orally effective versions of these derivatives are obtained by acylating the hydroxyl functions.