Procedure for obtaining acid compounds 7 - (N - Acyl - glicilamino) - 3 - (1 - alkyl (c1-c4) - 1H tetrazole thiomethyl - 5 - yl) - - 1 - oxadetia - 3-cephem-4-carboxylic - carboxylic acid and its Salts

摘要

Antibacterial 7-substituted aminoacetamido oxadethiacephalosporins of the formula: IMAGE [wherein R is substituted amino, substituted phenyl, or 5- or 6-membered hetero ring; Ar is aryl; Y is hydrogen or methoxy; Het is 5- or 6-membered aromatic hetero ring; and Z is hydroxy or carboxy protecting group] preparable e.g. by acylation of 7 alpha -methoxy-7 beta -amino-3-heterocyclic thiomethyl-3-cephem-4-carboxylic acid derivatives, are highly active against gram-positive and gram-negative bacteria, especially those resistant to other cephalosporins and penicillins.