Cyclic analog of naturally occurring phagocytosis-stimulating peptide-threonyl-cyclo nepseilin-lysyl-prolyl-arginyl).

摘要

PCT No. PCT/SU80/00060 Sec. 371 Date Dec. 12, 1980 Sec. 102(e) Date Dec. 12, 1980 PCT Filed Apr. 2, 1980 PCT Pub. No. WO80/02141 PCT Pub. Date Oct. 16, 1980.A novel substance, that is a cyclic analogue of a naturally-occurring phagocytosis-stimulant peptide - threonyl-cyclo-[-N epsilon -lysyl-prolyl-arginyl-] of the formula: IMAGE A method for preparing threonyl-cyclo-[-N epsilon -lysyl-prolyl-arginyl-] by way of a step-wise building-up of the peptide chain from the C-terminal by means of activated ethers of benzyloxycarbonyl-proline, tert.butyloxycarbonyl- -N epsilon -benzyl-oxycarbonyl-lysine and tert.butyloxycarbonyl-threonine, followed by cyclization of the resulting partly blocked tetrapeptide using Woodward reagent in an excess of dimethylformamide and isolation of the desired product.