PROCESS FOR THE PRODUCTION OF 17A-METHYL-3-PYRROLIDINO-17A-AZA-D-HOMOANDROST-5-ENE DIMETHIODIDE (CHANDONIUM IODIDE)

摘要

Process for the production of 17a-methyl-3b-phrrolidine -17a-aza-D-homoandrost-5-ene dimethlodide (Chrrderium Iodide) of the figure 4, comprising (i) reacting pyrrolidine with 17a-methyl-17a-za-D-homoandrost-4-en-3-one of figure 1, to obtain 17a-methyl-3-pyrrolidine -17a-aza-D-homoandrost -3, aliene of figure 2, (ii) subjecting the amc compound to reduction the obtain 17a-methyl-3b-pyrrolidine-17a-aza-D-homoandrost-5-ene of figure 3, and (iii) quternising the reaction product with methyl iodide to obtain the desired compound of figure 4.