Procedure for Preparation of N- (2- (((5- ((dimeti-lamino) methyl) -2-furanyl) methyl) thio) ethyl) -N'-methyl-2-nitro-1,1-ethenediamine

摘要

Process for the production of N - (2 - ((4 - dimethylamino) methyl) - 2 - furanil) methyl) thio) ethyl) - n '- methyl - 2 - nitro - 1.1 - etenodiamina.Is to react the hydrochloride of 5 - (dimethylamino) methyl 2 - (Chloromethyl) - Furan with N - (2-mercaptoethyl) - n '- methyl - 2 - nitro - 1.1 - etenodiamina in an organic Solvent such as Methanol, isopropanol, acetone, or their mixtures with water and in the presence of a base such as Sodium hydroxide or squid Ico.The Reagents are used preferably according to the molar ratio 1:1 Stoichiometric reaction. The process is performed at a temperature between 5 and 15. After the Reaction, the product was separated by Filtration and then Purified by recrystallization in a solvent.For use in the treatment of gastroduodenal ulcers and all the syndromes accompanied by gastric secretion.