Process for the preparation of a 1- (alkylamino) -2-nitroethenthiol potassium salt, process for the preparation of an N-substituted 1-alkylthio-2-nitroethenamine, process for the preparation of N- 2- 5- (dimethylamino) methyl-2 -furanylmethylthio -ethyl -N'-methyl-2-nitro-1,1-ethenediamine (ranitidine) and 1 - 2 - 5 - (dimethylamino) methyl -2-furanyl methyl -thio -ethyl -amino -2-nitroethenthiol potassium salt

摘要

A potassium salt useful in the production of N-substituted-1-alkylthio-2-nitroethenamines is produced by the reaction of the dipotassium salt of nitrodithioacetic acid with certain straight chain alkylamines, thereby converting only one of the KS-groups to an alkylamine group. The resulting monopotassium salt may be alkylated to produce the required N-substituted-1-alkylthio compound which may be reacted with a suitable amine to produce the histamine H2-antagonist ranitidine.