A process for the preparation of precursor of Allyl sulfoxides inhibitors of Oak trees.

摘要

Method for preparing precursor of alilsulfoxidos Enzyme inhibitors of Structural formula (i), wherein R is phenyl, phenyl substituted with an electron withdrawing Group, or an Aromatic heterocycle trihalometilo five or six members; R is Hydrogen or aminometilo increased to 1; R Square R High and 5 are Hydrogen; R Cube is a group easily outgoingOr R R Square and Cube together form a double Bond; R is Hydrogen or a high 4 electron acceptor Group; R is Hydrogen or High 6 - COOH, and R is raised to 7 - Oh, - NH2, - SH and CH2OH.A man is to oxidize Aromatic Derivative of Structural formula (ii) wherein R and R increased to 1 - 7 have the meaning indicated above, with the exception of any of the substituents R high to 1 - 7 is sensitive to oxidation is provided with a protecting Group. After oxidation the Protecting Group is removed.The oxidizing Agent is selected from 1 - clorobenzotriazol, Cl2, Br2, naio4, ch3coono2o a peracido. * * n formula