CIS-PLATINUM (II) AMINE ASCORBATE COMPLEXES

摘要

Ascorbate complexes of platinum (II) coordinated to ammonia or monodentate or bidentate amine ligands in a cis configuration represented by the general formula: cis-[Pt(II)A2(X)m(OH)n] wherein A is ammonia or an amine ligand; X is the ascorbate moiety; m is from 1 to 2 and n is from 1 to 0 and the sum of m + n is not greater than 2. The compounds are characterized by pronounced anti-tumor activity, high solubility in water, and low animal toxicity.