AbstractAscorbate complexes of platinum(II) coordinatedto ammonia or monodentate or bidentate amine ligands in acis configuration represented by the general formula:cis-[Pt(II)A2(X)m(OH)n]wherein A is ammonia or a monodentate alkyl amine ligand;A2 is a bidentate amine ligand; X is the ascorbate moiety;m is from 1 to 2 and n is from 1 to 0 and the sum of m + nis not greater than 2. The compounds are characterized bypronounced anti-tumor activity, high solubility in water,and low animal toxicity.
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