Living virus culture vaccine against canine distemper - comprising attenuated strain epm. 10-76 obtd. from mink having distemper

摘要

Living virus culture vaccine against canine distemper comprises an attenuated strain EPM No. 10-76 obtd. from the wield virus. It is isolated from a mink having distemper by multiple passage of the virus on (1) dog kidney cell culture, (2) continuous cell culture of the kidneys of the human embryo Rh and (3) mixed culture of dog kidney cells and Japanese quail embryo cells, adapted to the Japanese quail embryo cell culture and grown on this cell culture. The vaccine is harmless, it does not produce toxic effects on admin. and it is obtd. economically. The vaccine has high antigenic activity, it produces effective and persistent immunity in treated animals and vaccination in the epizootic foci of canine may be distemper rapidly eradicates infection. The vaccine may be given parenterally or in aerosol form, and since it is highly active, the amts. required for 1-500 doses can easily be filled into vials.