Amino derivs. of 1,2-benzisothiazole - beta:sympatholytics suitable for the treatment of coronary heart disease, hypertonia and cardiac arrhythmia

摘要

Novel amino-derivs. of 1,2-benzisothiazole are of formula (I). n is 2 or 3; R1 and R2 are H or opt. branched 1-5C alkyl; R3 is Ph, opt. mono-, di- or tri-substd. by halogen, alkyl, alkoxy, alkylthio, haloalkyl or haloalkoxy (these 2 gps. contg. 1-3 halogen), hydroxyalkyl or alkoxyalkyl (all alkyl gps. contg. 1-5C), 2-6C alkenyl, alkinyl or alkinyloxy, 3-8 ring C cycloalkoxy, methylene dioxy, amino, 1-5C alkylamino or di(1-5C)alkylamino. R3 may also be indanyl or tetrabydropaphthyl). The physiologically acceptable acid addn.-salts of (I) are also new. (I) are pharmaceuticals and can be used in heart and circulatory disorders. As a result of their beta-sympatholytic action, (I) are esp. suitable for the treatment of coronary heart disease, hypertonia and disturbances of cardiac rhythm. Suitable unit doese for humans are 1-100 (sp. 3-50) mg. (I) are strong beta-sympatholytics of low toxicity and have a therapeutic breadth 3-12 times greater than that of the known beta-sympatholitic propandol.