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New derivatives of the androst 4 - ene, their process of preparation and their application as medicinal product
New derivatives of the androst 4 - ene, their process of preparation and their application as medicinal product
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机译:雄甾烯4-烯的新衍生物,制备方法及其在医药中的应用。
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摘要
Novel DELTA 4-androstenes of the formula IMAGE I' wherein R1 is alkyl of 1 to 3 carbon atoms, R' is an acyl of an organic carboxylic acid or carbonic acid of 1 to 18 carbon atoms, R2 is selected from the group consisting of alkyl of 1 to 12 carbon atoms, alkenyl of 2 to 12 carbon atoms, -CF3, aryl of 6 to 12 carbon atoms and aralkyl of 7 to 12 carbon atoms, Y is selected from the group consisting of hydrogen, fluorine and methyl, X is selected from the group consisting of hydrogen, chlorine, bromine and fluorine and the dotted lines in the A and B rings indicate one or 2 double bonds in 1(2) and 6(7) positions with the proviso when R1 is methyl and the B ring is saturated, X is hydrogen when Y is hydrogen and X is not hydrogen when Y is fluorine having a remarkable anti-inflammatory activity and their preparation.
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