Multiple injector flow through dissolution cell for dissolution testing apparatus

摘要

A dissolution cell for use in automatic dissolution testing apparatus is specially configured to accommodate the iterative insertion of product specimens into the dissolution mechanism flow stream, and to perform the specimen insertion into a stabilized flow stream with minimal insertion disturbance. A basic multiple-injection embodiment utilizes a linear configuration to selectively insert two specimens into the flow stream, and a circular multiple-injection embodiment teaches the selective insertion of a plurality of specimens into the stream in a manner amenable to a programmable sequence. Both embodiments use air evacuation of the specimen flow chamber prior to its insertion into the instrumented flow stream, and both allow a high degree of fidelity in the dissolution measurements performed. The improved cell is especially useful for testing rapidly dissolving industrial products or drug dosage forms.