PURPOSE:The reaction between a carboxylic chloride and a trialkylsilyl diazomethane is followed by the reaction of the product with an alcohol to produce an acid ester of the carbon chain extended by one carbon with no formation of side chain in high safety. CONSTITUTION:The reaction between a carboxylic chloride of formula I(R is alkyl, aryl) and a compound of formula II(R0 is 1-4C straight or branched chain alkyl) gives an intermediate assumed to have the structure of formula III. The reaction is conducted under anhydrous conditions at 50--30 deg.C. Then, the intermediate is made to react with an alcohol to give a carboxylic ester with the carbon main chain extended by one carbon atom from the carboxylic chloride. The reaction is carried out at 50-250 deg.C. Both reaction is effected in the presence of an amine. This process is safe, because toxic and explosive diazomethane is not employed.
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