new derivatives of 1 - benzyl - (4 - ((4 - (2 - pyrimidinylamino) benzyl 2,3 - dioxopiperazines, their salts, process for preparation of these derivatives and salts and carcinostatique containing agent

摘要

1-Benzyl-4-[4-(2-pyrimidinylamino)benzyl]- 2,3-dioxopiperazine derivatives represented by the formula: IMAGE wherein R1 is optionally substituted hydrocarbyl or acyl, R2 is H or alkyl and X is O or S, and salts thereof have an excellent carcinostatic activity but a low toxicity. Therefore, said compounds are useful as medicines and also as intermediates.