ANTIHEMOPHILIC FACTOR PREPARATION FROM HUMAN BLOOD PLASMA AND A PROCESS FOR PRODUCING IT

摘要

An antihemophilic factor preparation (AHF) of high solubility and long half-life is produced in high yields by complete or partial thawing of deep-frozen human blood plasma by irradiation with electromagnetic waves of a frequency of about 108-1015 for a period of time and with an energy penetration such that the temperature in the thawed plasma does not exceed 10 DEG C. at any point, and processing in a manner known per se by centrifuging the thawed product to form a cryoprecipitate, redissolving the cryoprecipitate in a buffer and isolating a concentrated solution which, if desired, is freeze-dried. Irradiation is preferably effected by microwaves of a frequency of 108-3x1011 Hz, in particular 2x109-3x1010 Hz, or by infrared light, said frozen plasma being preheated if desired. The preparation is suitable for injection performed by the patient himself without medical assistance.