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A method of preparing a quaternary salt of an ester of eritromicina.a.
A method of preparing a quaternary salt of an ester of eritromicina.a.
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机译:一种制备Eertromicina.a的酯的季盐的方法。
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摘要
High water-soluble erythromycin A derivatives wherein the desosamine moiety is quaternized with an acyloxy-, benzoyloxy- or alkoxycarbonyl-(or carboxy)-acylmethyl iodide, bromine or chloride and esterified in the 2-position with loweralkyl or -(CH2)nCO2R sec , wherein R sec is H, loweralkyl or substituted loweralkyl and n is an integer from 1-5. These new esters readily convert to erythromycin A upon administration to warm-blooded animals.
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