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A method for Preparation of a Quaternary Salt, an ester of eritromicina.a.
A method for Preparation of a Quaternary Salt, an ester of eritromicina.a.
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机译:一种季盐的盐的制备方法。
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摘要
A method for Preparation of a Quaternary Salt, an ester of erythromycin.Consists on making a 2 '' - Ester of erythromycin a with an ester halometilico formula rcoochr''''''x in which R is H or alkyl'''''' Lower and Lower unaradical R is alkyl, phenyl or Benzyloxycarbonyl (Lower alkyl, alkoxy optionally substituted with lower Bromine or chlorine.In the presence of a Polar Solvent and a aprotico carbonate or bicarbonate Alkaline combines temperature below 30 degrees Celsius and for a period of twenty-four hours at least, it is the compound (i) in which R is alkyl or phenyl; R is lower alkyl 'and X is Chlorine or Bromine, iodine.
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