Procedure for obtaining new 5-diazacicloalquil-imidazo (2,1-b) (1,3,5) benzothiadiazepines

摘要

The invention concerns the compounds of the Formula I IMAGE wherein each of R1 and R2 is hydrogen, alkyl, alkanoyl, halogeno, cyano, carboxy, carbalkoxy, carbamoyl, sulfamoyl, mono- or di-alkyl-(carbamoyl or sulfamoyl); Ph is 1,2-phenylene, unsubstituted or substituted by up to two identical or different members selected from alkyl, alkoxy, alkylthio, halogeno, trifluoromethyl, sulfamoyl, mono- or di-alkylsulfamoyl; each of CmH2m and CnH2n is alkylene separating both nitrogen atoms by 2 or 3 carbon atoms, and R3 is hydrogen, alkyl, alkanoyl, alkoxycarbonyl, phenyl-alkoxycarbonyl or hydroxyalkyl, wherein the hydroxy group is separated from the nitrogen atom by at least 2 carbon atoms; their N- and/or S-oxides, and alkyl quaternary derivatives thereof salts of all these compounds. The compounds exhibit neuroleptic activity. They are prepared by condensing a compound of the general Formula III or a salt thereof with a compound of the general Formula IV IMAGE wherein X is halogeno, alkoxy, alkylthio, cyanato or thiocyanato; Y is hydrogen or an alkali metal; p is an integer from 0 to 2, and the remaining symbols have the meaning given for formula I.