SELECTIVE CONVERSION OF 20-METHYL-PREGNA- 3,5,20(21)-TRIENE-3,21-DIOL-DIACETATE TO 3-OXO-20-METHYLPREGNA-4,20(21)-DIENE-21-YL-ACETATE

摘要

SELECTIVE CONVERSION OF 20-METHYLPREGNA-3,5,20(21)-TRIENE-3,21-DIOL-DIACETATE TO3-OXO-20-METHYLPREGNA-4,20(21)-DIENE-21-YL-ACETATEABSTRACT OF THE INVENTIONThe present invention relates to the conversion of 20-methylpregna-3,5,20(21)-triene-3,21-diol-diacetate to 3-oxo-20-methylpregna-4,20(21)-diene-21-yl-acetate through the useof a halogenated solvent and a halogenated acid. The benefitsof the present invention include a substantial increase in theproduation of progesterone via ozonolysis technology.